An open-access portal tracking research advances and datasets across Alzheimer’s disease, Parkinson’s disease, and ALS. Aggregating scientific findings and open repositories from Alzforum, bioRxiv, OpenNeuro, DANDI, and Agora.
Spatially resolved RNA imaging combined with sequencing maps cellular crosstalk across hippocampal subregions.
Subcellular MERFISH and single-nucleus RNA sequencing across human post-mortem white matter lesions map complement C1q signaling and interferon-responsive oligodendrocyte states at paramagnetic lesion rims.
Prospective multi-center validation across 1,420 MS patients demonstrating that elevated serum GFAP paired with paramagnetic rim lesions (PRLs) predicts 24-week confirmed PIRA independent of acute gadolinium-enhancing relapses.
A 24-month longitudinal cohort of 650 Parkinson’s patients monitored with wrist-worn IMU accelerometer arrays establishes automated machine learning scores correlating with MDS-UPDRS Part III subscores.
Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation.
A lack of early visual experience causes pronounced lasting auditory and visual cross-modal changes. However, the region-specific cross-modal organization of the visual cortex at the single-neuron level remains unknown. Here, we used two-photon calcium imaging in awake mice that were reared in darkn...
Distinguishing resident microglia from engrafted peripheral myeloid cells is important for interpreting CNS inflammation. P2RY12, TMEM119, and FCRLS are widely used to identify microglia, but their ability to distinguish cellular origin after prolonged engraftment remains context dependent. Using bo...
Precision medicine approaches require physiological effects to be informative when translated to the individual. Reliable group differences may have limited individual value when distributions overlap, mechanisms are heterogeneous, or patients differ in phenotype. A feature can differ between group ...
Navigation requires the brain to encode spatial relationships that support extrapolation from explored to unexplored regions of space. We identified a novel neural code for space in the mouse medial frontal cortex (mFC) that is well suited for this form of spatial generalization. Using calcium imagi...
Pyramidal tract (PT) neurons constitute a major cortical output pathway to subcortical structures, yet their contribution to parkinsonian and dyskinetic motor states remains unclear. Here, we show that chemogenetic activation of motor cortical PT neurons selectively confines pathological dopaminergi...
Neuronal activity alters synaptic protein composition, which is important for maintaining dendritic complexity. Multiple signaling networks have been implicated in these processes, but how increased neuronal activity regulates their expression remains incompletely understood. The long isoform of Ang...
Learning to stabilize an unstable object may depend not only on the accuracy of active corrective interventions but also on when to suspend intervention and allow the object's intrinsic dynamics to evolve. We investigated learning-related changes in control dynamics and associated beta-band electroe...
This portal tracks and synchronizes open CNS data based on the following criteria: