Open Datasets & Multi-Omics Portals

An exceptional multimodal neuroimaging repository providing 3T structural MRI, resting-state fMRI, and [18F]Florbetapir Amyloid-PET scans from 180 subjects formatted strictly to BIDS standard. This open dataset serves as a benchmark resource for deep learning and diagnostic biomarker discovery in early Alzheimer's and MCI.

This open-access 3T fMRI dataset evaluates striato-cortical circuit connectivity across 72 Parkinsonian patients and controls under levodopa ON vs. OFF states. Complete with behavioral logs, it offers foundational data for modeling dopaminergic network dynamics in motor execution.

The MSDA Core Dataset (CDS) establishes a 44-variable international harmonization schema mapped to the OMOP Common Data Model, enabling privacy-preserving federated analytics across global Multiple Sclerosis registries.

A centralized metadata discovery catalogue indexing over 30 national and international MS registries (>120,000 patients), detailing variable availability for EDSS, relapse history, MRI, fluid biomarkers, and DUA governance.

Provides high-resolution 3T/7T 3D-FLAIR, MP2RAGE, and QSM/SWI scans in BIDS format with voxel-wise annotations for paramagnetic rim lesions (PRLs) and the central vein sign (CVS), enabling automated chronic active lesion segmentation in Multiple Sclerosis.

A multi-center BIDS spinal cord MRI repository pairing 3D T1w/T2w/T2*w scans with Spinal Cord Toolbox (SCT) segmentation derivatives to quantify upper cervical cord cross-sectional area (CSA) and pyramidal tract demyelination in MS.

Single-nucleus and spatial transcriptomic atlas profiling over 185,000 nuclei across human MS lesion stages, identifying C1q-dependent Microglia Inflamed in MS (MIMS-iron and MIMS-foamy) and oligodendrocyte precursor differentiation arrest.