An open-access portal tracking research advances and datasets across Alzheimer’s disease, Parkinson’s disease, and ALS. Aggregating scientific findings and open repositories from Alzforum, bioRxiv, OpenNeuro, DANDI, and Agora.
A 24-month longitudinal cohort of 650 Parkinson’s patients monitored with wrist-worn IMU accelerometer arrays establishes automated machine learning scores correlating with MDS-UPDRS Part III subscores.
Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation.
Pyramidal tract (PT) neurons constitute a major cortical output pathway to subcortical structures, yet their contribution to parkinsonian and dyskinetic motor states remains unclear. Here, we show that chemogenetic activation of motor cortical PT neurons selectively confines pathological dopaminergi...
Parkinsons disease (PD) is defined by the preferential degeneration of neuromelanin (NM)-containing dopamine-producing neurons in the substantia nigra (SN), accompanied by intraneuronal inclusions rich in alpha-synuclein (aSYN). However, the mechanistic relationship between NM accumulation and aSYN ...
Loss of nigrostriatal dopamine (DA) neurons in Parkinson's disease (PD) produces motor symptoms by disrupting the normal circuitry of striatal projection neurons. Here, we report that the Transient Elevation of Dopamine (TED) within a defined window of 6-OHDA-induced DA depletion preserves normal mo...
There is accumulating evidence that the GLP-1 analog, semaglutide, might effectively curb intake of cocaine via brain dopaminergic functioning, despite limited brain penetrance. However, there is currently no established mechanism elucidating how chronic semaglutide treatment regulates the dopaminer...
Dermal fibroblasts were obtained from a 40-year-old male patient with Parkinson's disease (PD), harboring the c.213C>G (p.Ser71Arg) variant in the RAB32 gene. Induced pluripotent stem cells (iPSCs) were generated using the CytoTune-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific). The pre...
The opioid epidemic persists despite available pharmacotherapies for opioid use disorder (OUD), motivating interest in treatments targeting the motivational and neurochemical substrates of opioid seeking. Peripherally administered oxytocin (OT) attenuates drug seeking and consumption across substanc...
Dopamine, produced primarily in the midbrain, is required for movement and reward-based signaling all throughout life. Loss of dopaminergic function can result in changes to motor systems, mood, motivation, and cognition. Dopaminergic cell death or dopaminergic hypofunction are implicated in a varie...
Understanding how soluble monomeric alpha-synuclein transitions into pathological alpha-synuclein (Lewy bodies) has remained a central challenge in neurodegeneration. Existing models, largely based on treating cells and animals with pre-formed alpha-synuclein fibrils cannot account for the emergence...
Parkinsons disease progression is difficult to measure clinically because of variability in symptom presentation, disease trajectory, and response to symptomatic therapy. Here, we develop proteomic quality-control measures and refine clinical metrics of disease progression for longitudinal, high-thr...
BackgroundNo known treatments prevent Parkinsons disease (PD) onset or delay its progression. Prior observational studies of antihypertensive medications and PD risk have produced inconsistent findings and may be susceptible to confounding and reverse causation. MethodsWe applied a multi-stage anal...
This portal tracks and synchronizes open CNS data based on the following criteria: