MDS-UPDRS
Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale
MDS-UPDRS（国際パーキンソン病・運動障害疾患学会改訂版 統一パーキンソン病評価尺度）
1. Biological & Technical Mechanism
The MDS-UPDRS comprises four subscales: Part I (non-motor experiences of daily living, including cognition, mood, sleep, and autonomic dysfunction), Part II (motor experiences of daily living), Part III (clinician-scored motor examination assessing bradykinesia, rigidity, rest tremor, and postural instability in ON/OFF medication states), and Part IV (motor fluctuations and dyskinesias).
MDS-UPDRSは、パーキンソン病の臨床研究および治験におけるゴールドスタンダード評価尺度であり、Part I（認知・抑うつ・睡眠・自律神経症状などの非運動症状）、Part II（日常生活における運動症状）、Part III（医師による運動機能診察：無動・筋強剛・静止時振戦・姿勢反射障害のON/OFF状態評価）、Part IV（ウェアリングオフやジスキネジア等の運動合併症）の4パートから構成されます。
2. Open Science & Clinical Trial Significance
Longitudinal MDS-UPDRS scores are paired with DAT-SPECT imaging, CSF αSyn-SAA, and wearable accelerometer kinematics in MJFF and PPMI open datasets.
MJFF（マイケル・J・フォックス財団）のPPMIコホート等では、数年間にわたるMDS-UPDRSの縦断スコアが脳画像（DAT-SPECT・MRI）、髄液バイオマーカー、ウェアラブルセンサーデータと紐づけて公開されています。
Related Neuroscience Terms & Standards
Presynaptic neuronal protein encoded by SNCA whose misfolding and fibrillar aggregation form Lewy bodies in Parkinson's disease and Lewy body dementia.
Multidomain kinase/GTPase protein; activating mutations (such as G2019S) are the most common cause of autosomal-dominant Parkinson's disease.
High-temporal-resolution recording of postsynaptic cortical electrical potentials and neural oscillations (delta, theta, alpha, beta, gamma bands).
Non-invasive neuroimaging modality measuring blood-oxygen-level-dependent (BOLD) hemodynamic signals to map brain network activity and functional connectivity.
Open Datasets & Research Publications Related to MDS-UPDRS
Continuous High-Frequency Smartwatch Sensor Telemetry Predicts Parkinson’s Motor Fluctuation Subtypes
A 24-month longitudinal cohort of 650 Parkinson’s patients monitored with wrist-worn IMU accelerometer arrays establishes automated machine learning scores correlating with MDS-UPDRS Part III subscores.
Dandiset 000026: Subthalamic Nucleus Local Field Potentials (LFP) and Beta-Band Dynamics in Parkinson’s Patients
High-density intraoperative and chronically implanted deep brain stimulation (DBS) electrode recordings during motor resting and movement states from 34 patients with idiopathic PD.
OpenNeuro ds003505: Dopaminergic Striato-Cortical Circuit Connectivity in Parkinson’s Disease during Motor Execution
This open-access 3T fMRI dataset evaluates striato-cortical circuit connectivity across 72 Parkinsonian patients and controls under levodopa ON vs. OFF states. Complete with behavioral logs, it offers foundational data for modeling dopaminergic network dynamics in motor execution.
Pharmacological Inhibition of mTORC1 Reduces Neural Death and Damage Volume After MCAO by Modulating Microglial Reactivity
Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation.
Hunger reconfigures a reward learning circuit into a memory competent mode
Internal states such as hunger dynamically reshape activity across circuits to support resource seeking. Neuromodulation provides a means of controlling such physiological properties of neurons, but how this flexibility regulates memory networks remains unclear. Here, we describe how hunger reconfig...
Focal drug uncaging for the precise control of endogenous nicotinic receptors in behaving mice
Nicotinic acetylcholine receptors shape diverse brain functions, including reward, aversion, and pain, but dissecting their roles in vivo requires drug delivery with spatiotemporal precision that conventional pharmacology cannot provide. Here we establish in vivo photopharmacology of endogenous nico...
Disclaimer: This encyclopedia entry is intended for academic neuroscience research and data science reference only, and does not constitute medical advice.